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Evidence that nitric oxide mediates the cyclic GMP response to synaptic activity in the rat superior cervical
1Signal Transduction, Abbott Laboratories, IL 60064.
Brain Research
|December 4, 1992
Abstract:
Preganglionic nerve stimulation in the rat superior cervical ganglion (SCG) caused an increase in guanosine 3':5'-cyclic monophosphate (cyclic GMP) in a Ca(2+)-dependent manner. This increase was inhibited by oxyhaemoglobin, and blocked stereoselectively by an inhibitor of nitric oxide synthase, NG-nitro-L-arginine. Thus, nitric oxide or a similar substance appears to mediate the neuronal cyclic GMP response to synaptic activity in the rat SCG.