Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pleomorphic xanthoastrocytoma: some new observations.

N Kawano1

  • 1Department of Neurosurgery, Kitasato University School of Medicine, Kanagawa, Japan.

Clinical Neuropathology
|November 1, 1992
PubMed
Summary

Pleomorphic xanthoastrocytoma (PXA) is a rare brain tumor found in young patients. This study investigated its pathological features, suggesting a possible link between ordinary astrocytomas and PXA development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The need to devise government-spearheaded measures to prevent loneliness and isolation in conjunction with the spread of COVID-19 in Japan.

Public health·2021
Same author

Evaluation of the safety and efficacy of Glycyrrhiza uralensis root extracts produced using artificial hydroponic and artificial hydroponic-field hybrid cultivation systems.

Journal of natural medicines·2016
Same author

Lunar global shape and polar topography derived from Kaguya-LALT laser altimetry.

Science (New York, N.Y.)·2009
Same author

Phosphorylation of the MAPK pathway has an essential role in the acrosome reaction in miniature pig sperm.

Reproduction in domestic animals = Zuchthygiene·2008
Same author

Control of sperm motility and fertility: diverse factors and common mechanisms.

Cellular and molecular life sciences : CMLS·2008
Same author

Efficient engraftment of primary adult T-cell leukemia cells in newborn NOD/SCID/beta2-microglobulin(null) mice.

Leukemia·2005

Area of Science:

  • Neuro-oncology
  • Pathology
  • Neurosurgery

Background:

  • Pleomorphic xanthoastrocytoma (PXA) is a rare glial tumor with distinct histopathological features.
  • Understanding the origin and characteristics of PXA is crucial for diagnosis and treatment.

Purpose of the Study:

  • To investigate the pathological features of pleomorphic xanthoastrocytoma (PXA) in 14 Japanese cases.
  • To evaluate the potential origin and development of PXA.

Main Methods:

  • Retrospective analysis of 14 Japanese PXA cases.
  • Clinical data review, including patient demographics and CT imaging.
  • Histopathological examination of tumor tissues.

Main Results:

  • PXA typically affects young patients (average age 19 years) and presents as a superficial, well-circumscribed, contrast-enhancing mass, often with a cyst.
  • Histopathology reveals a pleomorphic, desmoplastic astrocytic tumor with chronic degenerative changes, including lipidization of tumor cells.
  • Desmoplasia is likely due to secondary proliferation of meningeal fibroblasts.

Conclusions:

  • PXA exhibits characteristic pathological features, including pleomorphism, desmoplasia, and lipidization.
  • While pial astrocytes are considered the likely origin, ordinary astrocytomas may evolve into PXA through meningeal invasion and desmoplasia induction.

Related Experiment Videos