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Activation of human herpesvirus-6 in children with acute measles

S Suga1, T Yoshikawa, Y Asano

  • 1Department of Pediatrics, Fujita Health University School of Medicine, Aichi, Japan.

Journal of Medical Virology
|December 1, 1992
PubMed

Insights

Measles infection may frequently activate human herpesvirus-6 (HHV-6) a few weeks later. Studies found increased HHV-6 antibodies and virus in children with acute measles.

Area of Science:

  • Virology
  • Immunology
  • Pediatrics

Background:

  • Investigating potential viral co-infections and reactivations in pediatric acute measles cases.
  • Assessing the role of human herpesvirus-6 (HHV-6) activation following measles infection.

Observation:

  • Prospective virological and serological studies were conducted on 50 infants and children diagnosed with acute measles.
  • Blood samples were analyzed for HHV-6 isolation and neutralizing antibody titers.
  • Epstein-Barr virus (EBV) antibody titers were also monitored for comparison.

Findings:

  • 90% of measles patients were seropositive for HHV-6 during the acute phase.
  • 40% showed a significant increase in HHV-6 antibody titers post-measles.
  • HHV-6 was isolated from peripheral blood mononuclear cells in three patients during early convalescence.
  • A significant rise in EBV VCA antibody titers was observed in only 2 out of 27 initially seropositive patients.

Implications:

  • Suggests frequent activation of HHV-6 occurs within weeks after primary measles infection in children.
  • Highlights a potential link between measles and HHV-6 reactivation.
  • Warrants further investigation into the clinical significance of HHV-6 reactivation post-measles.

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