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Treatment of human cutaneous sporotrichosis with itraconazole
I A Conti Díaz1, E Civila, E Gezuele
1Department of Parasitology, School of Medicine, University of the Republic, Montevideo, Uruguay.
Abstract:
Eighteen adult white male patients with cutaneous sporotrichosis were treated with itraconazole following different daily dose schemes. Cure was obtained in all cases after periods of 15-75 days (median 44 days) with total doses between 3.1 and 14.8 g (median 8.4 g). No serious side effects were observed and no relapses occurred in the follow-up period of between 1 and 26 months (median 14.7). These results show that itraconazole represents a safe and effective drug for the treatment of sporotrichosis. Comparison with other studies leads us to consider a daily dose of 200 mg as the most appropriate. A concomitant warming of the affected limbs should be recommended.
Insights
Itraconazole effectively treats cutaneous sporotrichosis in adult males, achieving cure in all patients without serious side effects. A daily dose of 200 mg is recommended for this fungal infection.
Area of Science:
- Mycology
- Dermatology
- Infectious Diseases
Background:
- Cutaneous sporotrichosis is a fungal infection caused by *Sporothrix schenckii*.
- Treatment options for sporotrichosis can have varying efficacy and side effect profiles.
Purpose of the Study:
- To evaluate the safety and efficacy of itraconazole for treating cutaneous sporotrichosis.
- To determine the optimal daily dosage of itraconazole for sporotrichosis treatment.
Main Methods:
- A study involving eighteen adult white male patients diagnosed with cutaneous sporotrichosis.
- Patients were treated with itraconazole using varied daily dosage regimens.
- Clinical outcomes, treatment duration, total dosage, side effects, and relapse rates were monitored.
Main Results:
- Complete cure was achieved in all 18 patients within 15-75 days (median 44 days).
- Total itraconazole doses ranged from 3.1 to 14.8 g (median 8.4 g).
- No serious adverse events or relapses were reported during follow-up (1-26 months, median 14.7 months).
Conclusions:
- Itraconazole is a safe and highly effective treatment for cutaneous sporotrichosis.
- A daily dose of 200 mg of itraconazole is suggested as the most appropriate regimen.
- Concomitant warming of affected limbs may be a beneficial adjunctive therapy.