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Related Experiment Videos

ACTH-like molecules in lymphocytes. A study in different vertebrate classes.

E Ottaviani1, A Franchini, A Cossarizza

  • 1Department of Animal Biology, University of Modena, Italy.

Neuropeptides
|December 1, 1992
PubMed
Summary

Adrenocorticotropic hormone (ACTH)-like molecules were found in blood lymphocytes of amphibians, reptiles, and birds. This suggests ACTH may regulate antibody responses in higher vertebrates.

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Area of Science:

  • Immunology
  • Endocrinology
  • Comparative Biology

Background:

  • Adrenocorticotropic hormone (ACTH)-like molecules are known to modulate macrophage functions across diverse species.
  • The presence and role of ACTH in blood cells of various vertebrate classes have not been fully elucidated.

Purpose of the Study:

  • To investigate the presence of ACTH-like molecules in blood cells of different vertebrate classes (Pisces, Amphibia, Reptilia, Aves).
  • To explore the potential role of ACTH in immune regulation within higher vertebrates.

Main Methods:

  • Immunocytochemical and cytofluorimetric analyses were employed.
  • Monoclonal and polyclonal antibodies were used to detect ACTH-like molecules.

Main Results:

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  • ACTH-like molecules were detected in lymphocytes of anuran amphibians, reptiles, and aves.
  • These molecules were not found in Pisces.

Conclusions:

  • Lymphocyte expression of ACTH-like molecules is a feature of higher vertebrates, starting from anuran amphibians.
  • ACTH may have acquired a novel regulatory role on antibody response in lymphocytes of higher vertebrates.