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Effect of some novel ethylenediamine and ethanolamine derivatives on carrageenan-induced inflammation. Correlation
I Andreadou1, E Rekka, V J Demopoulos
1Department of Pharmaceutical Chemistry, School of Pharmacy, University of Thessaloniki, Greece.
Abstract:
The effect of eight ethylenediamine and ethanolamine derivatives on inflammation was investigated in the carrageenan-induced rat paw edema model. The ability of these compounds to inhibit superoxide anion radical (O2-.) formation in vitro was also examined using the xanthine-xanthine oxidase system. Almost all of these substances were found to possess anti-inflammatory activity. This action can be well correlated with their reported capacity to inhibit microsomal membrane lipid peroxidation, while they demonstrated negligible effect on O2.- generation. The above actions appear to depend on some structural characteristics, particularly in the aromatic series of compounds.