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Related Experiment Videos

[Hematuric cystitis after bone marrow allograft: a case].

I Bontemps1, D Frappaz, F Levignes

  • 1Service de pédiatrie A, hôpital Nord, Saint-Priest-en-Jarez, France.

Pediatrie
|January 1, 1992
PubMed
Summary

Hemorrhagic cystitis, a severe bladder complication, can occur after allogeneic stem cell transplant. A conservative "watch-and-wait" approach with bladder irrigation can lead to spontaneous resolution.

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Area of Science:

  • Hematology
  • Oncology
  • Transplantation Medicine

Background:

  • Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative option for acute lymphoblastic leukemia (ALL).
  • Conditioning regimens, including cyclophosphamide and total body irradiation, precede HSCT and can cause significant side effects.
  • Hemorrhagic cystitis (HC) is a known complication post-HSCT, characterized by bladder inflammation and bleeding.

Observation:

  • A 16-year-old male developed severe macroscopic hemorrhagic cystitis 20 days after a partially mismatched allogeneic HSCT for ALL.
  • The patient's conditioning regimen consisted of cyclophosphamide and total body irradiation.
  • Gross hematuria persisted for 3 months.

Findings:

  • Conservative management, including intensive bladder irrigation, was initiated for the hemorrhagic cystitis.
  • The patient experienced spontaneous resolution of hematuria after a 3-month period.
  • Literature review highlights predisposing factors and clinical outcomes of HC post-HSCT.

Implications:

  • A conservative 'watch-and-wait' strategy may be effective for managing HSCT-related hemorrhagic cystitis.
  • Understanding predisposing factors is crucial for risk stratification and potential prevention.
  • This case underscores the importance of supportive care in managing transplant complications.

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