Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

AZT-induced mitochondrial myopathy.

G Tomelleri1, P Tonin, M Spadaro

  • 1Istituto di Neurologia, Università di Verona.

Italian Journal of Neurological Sciences
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Staged Bilateral Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for Essential Tremor: Prospective Single-Centre Cohort and Systematic Review With Meta-Analysis.

European journal of neurology·2026
Same author

Protein Expression of Canine and Feline Muscular Dystrophies.

Topics in companion animal medicine·2020
Same author

Functional and radiological outcomes after bridging therapy versus direct thrombectomy in stroke patients with unknown onset: Bridging therapy versus direct thrombectomy in unknown onset stroke patients with 10-point ASPECTS.

European journal of neurology·2020
Same author

Oxidative stress biomarkers in Fabry disease: is there a room for them?

Journal of neurology·2020
Same author

Iodine Extravasation Quantification on Dual-Energy CT of the Brain Performed after Mechanical Thrombectomy for Acute Ischemic Stroke Can Predict Hemorrhagic Complications.

AJNR. American journal of neuroradiology·2018
Same author

Evidence of ER stress and UPR activation in patients with Brody disease and Brody syndrome.

Neuropathology and applied neurobiology·2017

Zidovudine (AZT) therapy can lead to toxic myopathy in AIDS patients, causing mitochondrial dysfunction. Studies revealed muscle abnormalities and partial deficiencies in key enzymes like cytochrome c oxidase (COX).

Area of Science:

  • Biochemistry
  • Cell Biology
  • Neurology

Background:

  • Zidovudine (AZT) is a cornerstone antiretroviral therapy for Human Immunodeficiency Virus (HIV) infection.
  • Long-term AZT use has been associated with various toxicities, including myopathy.
  • The precise mechanisms underlying AZT-induced myopathy require further elucidation.

Purpose of the Study:

  • To investigate the histochemical, ultrastructural, and biochemical alterations in muscle tissue of AIDS patients undergoing zidovudine treatment.
  • To determine the association between zidovudine therapy and mitochondrial dysfunction in muscle.

Main Methods:

  • Histochemical staining of muscle biopsy specimens.
  • Electron microscopy for ultrastructural analysis of muscle mitochondria.

Related Experiment Videos

  • Biochemical assays to assess mitochondrial enzyme activity, including cytochrome c oxidase (COX) and succinate cytochrome c reductase (SCR).

    • Main Results:

    • Muscle biopsy specimens from 11 AIDS patients treated with zidovudine were analyzed.
    • Nine patients exhibited focal cytochrome c oxidase (COX) deficiency, with 8 on long-term treatment.
    • Electron microscopy revealed abnormalities in mitochondrial number, size, and structure; biochemical studies confirmed partial COX and SCR deficiencies in some patients.

    Conclusions:

    • Zidovudine (AZT) therapy is associated with toxic myopathy characterized by significant mitochondrial dysfunction.
    • Histochemical, electron microscopy, and biochemical findings consistently indicate impaired mitochondrial function in muscles of patients treated with AZT.
    • These results underscore the importance of monitoring for myopathy in patients receiving zidovudine therapy.