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Infectious minor lymphocyte stimulating (Mls) antigens
H Acha-Orbea1, G A Waanders, A N Shakhov
1Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland.
Seminars in Immunology
|October 1, 1992
Summary
Minor lymphocyte stimulating (Mls) antigens, encoded by mouse mammary tumor viruses (MMTV), significantly impact the murine immune system. This review compares the effects of infectious MMTV (Mls-1a) with endogenous Mtv-7 (Mls-1a) on immune tolerance.
Area of Science:
- Immunology
- Virology
- Genetics
Background:
- Minor lymphocyte stimulating (Mls) antigens are crucial for understanding immune tolerance.
- Mls antigens are encoded within the 3' long terminal repeat of mouse mammary tumor viruses (MMTV).
Purpose of the Study:
- To review and compare the effects of a novel infectious MMTV (Mls-1a) on the neonatal and adult immune system.
- To contrast these effects with those of the endogenous Mtv-7 (Mls-1a) antigen.
Main Methods:
- Comparative analysis of immune responses.
- Review of existing literature on MMTV and Mls antigens.
Main Results:
- Infectious MMTV (Mls-1a) exhibits distinct properties influencing the immune system.
- Endogenous Mtv-7 (Mls-1a) also plays a significant role in immune modulation.
Conclusions:
- Understanding MMTV-encoded Mls antigens is key to advancing knowledge of immune tolerance.
- Comparative studies highlight the diverse impacts of endogenous and infectious MMTV on immune development and function.