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Control of rat mammary-gland pyruvate dehydrogenase by insulin and prolactin
The Biochemical Journal
|May 15, 1976
Abstract:
Withdrawal of prolactin or of insulin from the circulation of lactating rats leads, within 3h, to increased inactivation by phosphorylation of mammary-gland pyruvate dehydrogenase. Prolactin may act by priming the tissue to respond directly to normal concentrations of circulating insulin and by this means be responsible for the increased activation of the enzyme during the course of normal lactation.