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Related Concept Videos

Hormonal Regulation01:33

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors01:30

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
Antihypertensive Drugs: Direct Renin Inhibitors01:25

Antihypertensive Drugs: Direct Renin Inhibitors

The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
Introduction to Urinary System01:13

Introduction to Urinary System

The urinary system consists of two kidneys, two ureters, the urinary bladder, and the urethra.
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
Blood and Nerve Supply to the Kidney01:18

Blood and Nerve Supply to the Kidney

The kidneys are vital organs responsible for filtering and cleaning blood, removing waste products, and regulating electrolyte levels. To perform these essential functions, they require a constant and robust blood supply.
Bloody Supply to the Kidneys:
The kidneys receive their blood supply from the renal arteries, which branch off from the abdominal aorta—the main artery supplying the abdomen and lower body. The renal arteries enter the kidneys at the hilum, a notch on the medial side of each...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...

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Articles linked to this work by shared authors, journal, and citation graph.

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Characteristics of 1,3-bis-(2-ethoxycarbonylchromon-5-yloxy)-2-((S)- lysyloxy)propane dihydrochloride (N-556), a prodrug for the oral delivery of disodium cromoglycate, in absorption and excretion in rats and rabbits.

Journal of pharmacobio-dynamics·1992
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[The surgical treatment for the Stanford type A aortic dissection].

[Zasshi] [Journal]. Nihon Kyobu Geka Gakkai·1992
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Isolation and characterization of a light-sensitive mutant of Escherichia coli K-12 with a mutation in a gene that is required for the biosynthesis of ubiquinone.

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[A case of aortic valve stenosis and regurgitation with idiopathic thrombocytopenic purpura].

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Composition of free long-chain (sphingoid) bases in stratum corneum of normal and pathologic human skin conditions.

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Related Experiment Video

Updated: Jul 22, 2026

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli
12:19

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli

Published on: June 27, 2015

[Renal kallikrein-kinin system].

K Nishimura1

  • 1Department of Respiratory Medicine, Ehime National Hospital.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|December 1, 1992
PubMed
Summary

The renal kallikrein-kinin system plays a role in blood pressure and kidney function. Researchers found its components within nephron cells, suggesting localized kidney regulation.

Area of Science:

  • Nephrology
  • Endocrinology
  • Molecular Biology

Background:

  • The renal kallikrein-kinin system (rKKS) is implicated in regulating blood pressure, sodium/water balance, renal vascular resistance, and renin release.
  • Understanding the precise localization and cellular sources of rKKS components within the kidney is crucial for elucidating its physiological roles.

Purpose of the Study:

  • To investigate the presence and synthesis of kallikrein and kininogen within different nephron cell types.
  • To discuss the localization of rKKS components in the kidney and their relationship to renal function, especially in light of new kinin receptor findings.

Main Methods:

  • Ultrastructural immunocytochemistry was employed to visualize protein localization.
  • In situ hybridization and polymerase chain reaction (PCR) with cDNA probes were used to detect and quantify gene expression and synthesis.

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A "Dual-Addition" Calcium Fluorescence Assay for the High-Throughput Screening of Recombinant G Protein-Coupled Receptors
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Last Updated: Jul 22, 2026

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli
12:19

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli

Published on: June 27, 2015

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
12:03

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors

Published on: June 7, 2016

A "Dual-Addition" Calcium Fluorescence Assay for the High-Throughput Screening of Recombinant G Protein-Coupled Receptors
08:46

A "Dual-Addition" Calcium Fluorescence Assay for the High-Throughput Screening of Recombinant G Protein-Coupled Receptors

Published on: December 2, 2022

Main Results:

  • Kallikrein and kininogen were detected and found to be synthesized in various cell types throughout the nephron.
  • The study confirms the presence of key components of the renal kallikrein-kinin system within the kidney's functional units.

Conclusions:

  • The findings support the localized synthesis and action of the renal kallikrein-kinin system within the nephron.
  • This localized system likely contributes significantly to the regulation of renal hemodynamics and salt/water homeostasis.