Related Experiment Video
Updated: Aug 16, 2026

Assessment of Mitochondrial Functions and Cell Viability in Renal Cells Overexpressing Protein Kinase C Isozymes
Published on: January 7, 2013
[Molecular biology of cytochrome P450 in kidney]
Abstract:
Cytochrome P450-catalyzed monooxygenation system is widespread in nature and many isoforms have been found in almost all the tissues of vertebrates. In the kidney, several isoforms of cytochrome P450 families, CYP1, 2, 3, 4, 24, 27 have been characterized by biological, immunochemical and molecular biological techniques. These cytochrome P450 isoforms are localized in the endoplasmic reticulum or mitochondria of kidney cortex and functional in the monooxygenation of a number of substrates, such as steroids, fatty acids, xenobiotics, and vitamin D. Particularly, hydroxylation of vitamin D at positions of 1 and 24 is known to be one of the most important functions of kidney specific P450 isoforms.
More Related Videos
Related Concept Videos
Kidney Structure
Drug Elimination by Renal Route: Tubular Secretion
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
Pharmacogenetics of Phase I Enzymes: Cytochrome P450 Isozymes
Bioactivation and Tissue Toxicity

