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Serum lipoprotein (a) in men with proteinuria due to idiopathic membranous nephropathy

C D Short1, P N Durrington, N P Mallick

  • 1Department of Renal Medicine, Royal Infirmary, Manchester, UK.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|January 1, 1992
PubMed

Insights

Patients with active proteinuria show elevated levels of Lipoprotein (a) (Lp(a)), a factor linked to heart disease and thrombosis. This finding may explain increased vascular risks in these patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Lipid Metabolism

Background:

  • Proteinuria is associated with increased risks of venous thrombosis and coronary heart disease (CHD).
  • Patients with heavy proteinuria often display altered lipoprotein metabolism.
  • Lipoprotein (a) (Lp(a)) is a known risk factor for CHD and may promote thrombosis.

Purpose of the Study:

  • To investigate serum Lipoprotein (a) (Lp(a)) concentrations in men with active idiopathic membranous nephropathy (IMN) compared to those in remission and healthy controls.

Main Methods:

  • Serum Lp(a) levels were measured in three groups: 10 men with active IMN, 8 men with IMN in remission, and 103 healthy men.
  • Statistical analysis was performed to compare Lp(a) levels across the groups.

Main Results:

  • Serum Lp(a) levels were significantly elevated in men with active IMN (median 31.3 mg/dl) compared to men in remission (median 8.4 mg/dl) and healthy controls (median 11.3 mg/dl).
  • Lp(a) levels in men with IMN in remission were similar to those in healthy controls.

Conclusions:

  • Elevated serum Lp(a) levels are present in men with active idiopathic membranous nephropathy.
  • High Lp(a) may contribute to the increased vascular morbidity (atherogenesis and thrombosis) observed in patients with proteinuria.

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