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Bone metastasis in ovarian cancer
L Kumar1, V L Bhargava, R C Rao
1Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi.
Asia-Oceania Journal of Obstetrics and Gynaecology
|December 1, 1992
Summary
Bone involvement in ovarian cancer is rare but indicates a poor prognosis. Treatment with chemotherapy and radiation showed some response in patients with bone metastasis.
Area of Science:
- Oncology
- Skeletal Metastasis
Background:
- Bone involvement is an uncommon complication of ovarian cancer.
- This study reviews cases of ovarian cancer with bone metastasis.
Observation:
- Four cases of ovarian cancer with bone involvement were identified over three years.
- Patients experienced severe bone pain, swelling, and mobility issues.
- Common sites included vertebrae, pelvis, and skull, with osteolytic lesions.
Findings:
- Three of four patients had concurrent abdomino-pelvic disease.
- Chemotherapy (cisplatin-based) plus radiation yielded significant responses in two patients (one complete, one partial).
- Median survival after bone metastasis was 7.5 months.
Implications:
- Ovarian cancer with bone metastasis is associated with a poor prognosis.
- Early identification and management of skeletal complications are crucial.
- Further research into optimizing treatment for bone metastasis in ovarian cancer is warranted.