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Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
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Published on: May 2, 2013

Failure to transfer tuberculin sensitivity passively with plasma fractions containing alpha globulin

N J EHRENKRANZ, B H WAKSMAN

    The Journal of Experimental Medicine
    |December 1, 1956
    PubMed

    We are unable to confirm the observations reported by Cole and Favour that passive transfer of plasma fractions containing alpha globulin (IV + V or IV-10) from tuberculin-sensitive guinea pigs confers delayed sensitivity to tuberculoprotein upon normal animals. In guinea pigs with chronic cervical adenitis due to infection with group C hemolytic streptococci, injection of fraction IV + V and repeated skin tests with PPD induced indurated skin reactions of 9 to 10 mm., maximal at 24 hours, and, in one experiment, a positive tissue culture response to tuberculin. It is suggested that this reactivity was actively induced. Normal or infected recipients of fraction I + II + III from the plasma of tuberculin-sensitive donors manifested edematous responses to tuberculopolysaccharide, maximal at 4 to 6 hours, as reported. Skin tests with pneumococcal C polysaccharide revealed no evidence of passive transfer of C-reactive protein in fractions I + II + III or IV + V.

    Keywords:
    SERUM GLOBULINTUBERCULIN REACTION

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