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Gastric secretory function in the developing human stomach.

E J Kelly1, K G Brownlee, S J Newell

  • 1Department of Anatomy, University of Leeds, UK.

Early Human Development
|December 1, 1992
PubMed
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Gastric parietal cells are present and functional from the first trimester of fetal development. However, their activity significantly decreases in infants after birth.

Area of Science:

  • Gastroenterology
  • Developmental Biology
  • Histology

Background:

  • Limited data exists on gastric parietal cell activity in premature infants.
  • Understanding early gastric function is crucial for infant health.

Purpose of the Study:

  • To investigate the presence, location, and maturity of gastric parietal cells in developing human fetuses and infants.
  • To assess the potential for gastric acid and intrinsic factor secretion during early development.

Main Methods:

  • Utilized standard histological techniques.
  • Employed antibodies targeting H+/K+ ATPase (proton pump) and intrinsic factor.
  • Examined 35 fetal specimens (13-28 weeks) and 5 infant specimens (2-21 weeks).

Main Results:

Related Experiment Videos

  • Parietal cells were identified in the body, antrum, and pyloric regions of all fetal specimens.
  • Parietal cell activity was observed in a mature, functional form from the end of the first trimester.
  • A marked decrease in parietal cell activity was noted in the infant specimens compared to fetal specimens.

Conclusions:

  • Developing human stomachs possess mature, functional parietal cells capable of secreting gastric acid and intrinsic factor by the end of the first trimester.
  • Parietal cell activity appears to diminish significantly after birth in early infancy.