Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dexfenfluramine and appetite in humans.

J E Blundell1, A J Hill

  • 1Department of Psychology, University of Leeds, UK.

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
|December 1, 1992
PubMed
Summary

Dexfenfluramine reduces daily energy intake by decreasing meal size and snacking frequency, leading to weight loss. This appetite suppressant effect, linked to serotonin, persists long-term, aiding weight management.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Examining the roles of body composition, energy expenditure and substrate metabolism in the control of daily energy intake in adolescents with obesity.

International journal of obesity (2005)·2025
Same author

Associations of sociodemographic factors and obesity in children: Insights from the hyperglycaemia and adverse pregnancy outcome Belfast study - CORRIGENDUM.

The Proceedings of the Nutrition Society·2023
Same author

The acceptability of a peer-led intervention to promote healthy dietary behaviours among adolescents in the school-setting: a qualitative investigation - CORRIGENDUM.

The Proceedings of the Nutrition Society·2023
Same author

Satiety responsiveness but not food reward is modified in response to an acute bout of low versus high intensity exercise in healthy adults.

Appetite·2019
Same author

Physical activity, eating traits and weight in young adulthood: a cross-sectional and longitudinal study.

Obesity science & practice·2019
Same author

Homeostatic and neurocognitive control of energy intake in response to exercise in pediatric obesity: a psychobiological framework.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2018

Area of Science:

  • Pharmacology
  • Neuroscience
  • Obesity Research

Background:

  • Serotonin systems are implicated in regulating satiety.
  • Appetite regulation is crucial for weight management.

Purpose of the Study:

  • To investigate the effects of dexfenfluramine on energy intake and eating patterns.
  • To explore the role of dexfenfluramine in appetite modulation and weight loss.

Main Methods:

  • Assessment of daily energy intake.
  • Analysis of meal size and snacking frequency.
  • Evaluation of perceived hunger levels.
  • Long-term treatment observation (12 months).

Main Results:

  • Dexfenfluramine reduced daily energy intake by 13-25%.
  • Decreased meal size (11-40%) and snacking frequency were observed.
  • Reduced perceived hunger, particularly postprandially.
  • Sustained appetite control and weight loss over 12 months.

Conclusions:

  • Dexfenfluramine enhances food's satiating power, modulating eating patterns.
  • The drug aids overweight individuals in appetite management for weight loss and prevention of regain.
  • Serotonin pathways likely mediate dexfenfluramine's satiety-enhancing effects.

Related Experiment Videos