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Decreased phosphodiesterase activity in cholera toxin-induced hypersecretion in suckling rats
Aye-Kyaw1, Kyi-Kyi-Myint, Tin-OO
1Biochemistry Division, Department of Medical Research, Yangon, Myanmar.
Japanese Journal of Medical Science & Biology
|August 1, 1992
Abstract:
During cholera toxin (CT)-induced hypersecretion in suckling rats, the rise in the intestinal cAMP concentration was found to be accompanied by a decrease in the cAMP-phosphodiesterase activity. The results suggest the involvement of phosphodiesterase (PDE) as one of the factors governing the rise of cAMP.