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[Cellular calcium, vasoconstriction, hypertension].

G Bruschi1, G Regolisti, A Borghetti

  • 1Istituto di Clinica Medica e Nefrologia, Università degli Studi di Parma.

Annali Italiani Di Medicina Interna : Organo Ufficiale Della Societa Italiana Di Medicina Interna
|July 1, 1992
PubMed
Summary
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Hypertension involves altered calcium handling in vascular cells, impacting blood pressure regulation. Understanding these calcium changes is key for developing new antihypertensive therapies.

Area of Science:

  • Cardiovascular Physiology
  • Molecular Biology

Context:

  • Vasomotion control is crucial for blood pressure regulation and a target for antihypertensive treatments.
  • Calcium ions (Ca++) act as the final messenger in muscle contraction.
  • Both calcium influx and calcium sensitization mechanisms are vital in regulating vascular tone.

Purpose:

  • To explore the role of intracellular calcium (Ca++) in the pathophysiology of hypertension.
  • To review recent findings on calcium handling in vascular and cardiac myocytes.
  • To highlight alterations in cell calcium control associated with different forms of hypertension.

Summary:

  • Vasoconstrictors increase Ca++ entry and sensitize the contractile apparatus, while vasodilators have opposing effects.
  • Studies show increased vascular myoplasmic Ca++ and enhanced calcium influx via dihydropiridine-sensitive channels in animal models of hypertension.

Related Experiment Videos

  • Elevated cytoplasmic Ca++ in platelets has been observed in hypertensive patients.

    • Impact:

    • Altered cell calcium control mechanisms may significantly contribute to the development and progression of hypertension.
    • Findings emphasize the importance of calcium signaling pathways in cardiovascular homeostasis.
    • This research provides a basis for exploring novel therapeutic strategies targeting calcium dysregulation in hypertension.