Determination of disodium clodronate in bulk material and pharmaceuticals by ion chromatography with post-column...

A validated ion chromatographic method for the determination of disodium clodronate in bulk material and pharmaceuticals is described. Separations are performed on a poly(styrene-divinylbenzene) copolymer column using 40 mM nitric acid as mobile phase at a flow rate of 0.5 ml min-1. The analyte is detected by UV absorption at 300 nm after post-column derivatization with acidic iron(III) solution (0.25 ml min-1). The proposed ion chromatographic method is validated in terms of selectivity, precision, linearity, accuracy and ruggedness.