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[High energy shockwave-induced acute changes in renal function].

B Y Li1

  • 1Department of Urology, Tongji Hospital, Tongji Medical University, Wuhan.

Zhonghua Yi Xue Za Zhi
|September 1, 1992
PubMed
Summary
This summary is machine-generated.

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Extracorporeal shock wave lithotripsy (ESWL) can cause temporary kidney damage, indicated by increased urinary markers. Higher energy levels correlate with more severe, longer-lasting renal tubular injury in nephrolithiasis patients.

Area of Science:

  • Nephrology
  • Urology
  • Biomedical Engineering

Context:

  • Nephrolithiasis (kidney stones) affects a significant portion of the population.
  • Extracorporeal shock wave lithotripsy (ESWL) is a common treatment for kidney stones.
  • Understanding the renal impact of ESWL is crucial for patient management.

Purpose:

  • To investigate the effects of varying Extracorporeal Shock Wave Lithotripsy (ESWL) pulse counts on renal function.
  • To identify biomarkers indicative of renal tubular damage following ESWL.
  • To correlate ESWL energy levels with the severity and duration of renal functional changes.

Summary:

  • Forty nephrolithiasis patients undergoing ESWL were divided into four groups receiving 1,500 to 3,000 pulses at 12.5 kV.
  • Urinary markers (NAG, beta 2MG, ALB) and serum beta 2MG significantly increased post-ESWL, indicating acute tubular changes.

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  • Higher pulse counts (≥2,500) correlated with more pronounced and persistent elevations in urinary NAG and beta 2MG, suggesting dose-dependent renal tubular damage.

    • Impact:

    • ESWL induces transient renal functional changes and acute tubular damage.
    • Renal tubular damage may persist beyond seven days, particularly with higher energy ESWL (≥2,500 pulses).
    • Urinary NAG and beta 2MG serve as sensitive indicators of ESWL-induced renal tubular injury.