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In-vitro activity of daptomycin against a worldwide collection of methicillin-resistant Staphylococcus aureus
W Brumfitt1, J M Hamilton-Miller
1Department of Medical Microbiology, Royal Free Hospital School of Medicine, London, UK.
Drugs Under Experimental and Clinical Research
|January 1, 1992
Abstract:
Minimum inhibitory and minimum bactericidal concentrations (MIC and MBC) of daptomycin and of vancomycin have been compared against 80 strains of methicillin-resistant Staphylococcus aureus isolated from many parts of the world. In the presence of 30 mg/l of Ca++, daptomycin at 4 mg/l killed all the strains tested, and was only slightly less active than vancomycin.