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Related Experiment Videos

ACE inhibition in the tissues.

T Unger1, P Gohlke

  • 1Department of Pharmacology, University of Heidelberg, Germany.

Clinical Physiology and Biochemistry
|January 1, 1992
PubMed
Summary

The study explores the concept of tissue-specific renin-angiotensin systems (RAS) independent of hormonal RAS. It highlights ongoing challenges in understanding the precise localization and function of RAS components within various organs.

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Area of Science:

  • Cardiovascular Physiology
  • Endocrinology
  • Molecular Biology

Background:

  • The discovery of renin-angiotensin system (RAS) components in tissues suggests localized, independent "tissue" RAS.
  • Detection of RAS component mRNA in organs further supports the existence of tissue-specific systems.
  • Angiotensin-converting enzyme (ACE) inhibitors have fueled interest in "tissue" RAS due to observed effects potentially linked to local inhibition.

Purpose of the Study:

  • To critically evaluate the concept of "tissue" renin-angiotensin systems.
  • To address conceptual problems and uncertainties regarding the localization and activity of RAS components in specific tissues.
  • To clarify the role of local ACE activity in vascular, cardiac, adrenal, and renal tissues.

Main Methods:

  • Review of existing literature on RAS component localization and activity.
  • Analysis of evidence regarding mRNA expression of RAS components in various organs.
  • Evaluation of studies investigating the effects of ACE inhibitors on "tissue" RAS.

Main Results:

  • The precise localization and activity of ACE within vascular endothelial cells remain unclear.
  • Evidence suggests ACE is not localized in the vascular media but may be active in the adventitia.
  • Unequivocal evidence for local angiotensin II production by ACE in cardiac tissue (outside coronary vessels) is lacking.
  • The exact sites of angiotensin II generation within tissue RAS in the adrenal gland and kidney are not fully elucidated.

Conclusions:

  • The model of distinct "plasma" versus "tissue" RAS faces significant conceptual challenges.
  • Further research is required to definitively establish the presence, localization, and function of "tissue" RAS in various organs.
  • Clarifying local RAS activity is crucial for understanding its physiological and pathological roles.

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