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[Wilms' tumor. Its multidisciplinary management].

R Rivera Luna, G Martínez Guerra, J Ruano Aguilar

    Gaceta Medica De Mexico
    |March 1, 1992
    PubMed
    Summary
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    Wilms tumor prognosis depends on clinical stage and histology. Early stages with favorable histology have an 82% survival rate, suggesting chemotherapy over radiotherapy.

    Area of Science:

    • Pediatric Oncology
    • Cancer Research
    • Clinical Pathology

    Context:

    • Wilms tumor is a common pediatric kidney cancer.
    • Accurate staging and histopathological subtyping are crucial for treatment planning.

    Purpose:

    • To identify prognostic factors in pediatric Wilms tumor.
    • To evaluate treatment strategies based on stage and histology.
    • To determine survival rates in a cohort of affected children.

    Summary:

    • This study analyzed 115 children with Wilms tumor, with Stage II being predominant. Prognostic factors included clinical stage and histology. Patients in Stages I and II with favorable histology benefited from chemotherapy over radiotherapy, achieving an 82% five-year survival rate.
    • Unfavorable histology correlated with advanced stages (II and IV) and poorer outcomes.

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  • Statistical significance was observed in disease-free survival between early (I-II) and advanced (III-IV) stages (p=0.01), and between unfavorable and favorable histology (p=0.01).

    • Impact:

    • Findings support tailored treatment protocols for Wilms tumor, optimizing chemotherapy and radiotherapy use.
    • Highlights the importance of multidisciplinary management for improving pediatric cancer outcomes.
    • Provides valuable data for refining prognostic models and treatment guidelines in pediatric nephroblastoma.