[Antibacterial and detoxification therapy in acute appendicitis]

Area of Science:

• Surgery
• Infectious Diseases
• Medical Technology

Background:

• Acute appendicitis is a common surgical emergency.
• Treatment strategies have evolved, incorporating various therapeutic modalities.
• Understanding the efficacy of different treatments based on appendicitis severity is crucial.

Purpose of the Study:

• To analyze the clinical effectiveness of antibacterial therapy, photomodification of autoblood, and hemosorption in patients with acute appendicitis.
• To determine optimal treatment protocols for different stages of acute appendicitis.

Main Methods:

• A clinical analysis was conducted on 395 patients diagnosed with acute appendicitis.
• Evaluated the outcomes of antibacterial therapy, photomodification of autoblood, and hemosorption, individually and in combination.
• Stratified treatment efficacy based on appendicitis classification (catarrhal, phlegmonous, gangrenous, peritonitis).

Main Results:

• Catarrhal appendicitis did not require antibacterial or desintoxicating therapy.
• Prophylactic photomodification of autoblood was most effective postoperatively for phlegmonous appendicitis.
• Gangrenous appendicitis demonstrated improved outcomes with a combination of antibacterial therapy and photomodified autoblood.
• Appendicular diffuse suppurative peritonitis showed the best results with a triple therapy: antibacterial therapy, photomodification of autoblood, and hemosorption.

Conclusions:

• Treatment for acute appendicitis should be tailored to the specific pathological stage.
• Photomodification of autoblood and hemosorption represent valuable adjunctive therapies in managing complicated appendicitis.
• Optimized therapeutic combinations can improve clinical outcomes and reduce the need for extensive interventions in certain appendicitis cases.