[A study of cyclic nucleotide acids in the serum in patients with myasthenia gravis]
1Department of Neurology, Tongji Hospital, Tongji Medical University, Hubei.
Zhonghua Shen Jing Jing Shen Ke Za Zhi = Chinese Journal of Neurology and Psychiatry
|December 1, 1992
Abstract:
The levels of cAMP and cGMP in serum of 100 patients with myasthenia gravis have been measured by 125I-RIA. The results showed that cAMP and cGMP were higher in the patients than in the controls significantly (P < 0.001). In 33 cases of these patients after using anticholinesterase drugs and prednisone, the levels of cAMP and cGMP reduced significantly. According to our study, we presumed that there would be cyclic nucleotide acid metabolic disturbances in patients with MG and cAMP might play a regulatory role in morbidity of MG.
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