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A brief review of the Ah locus
1McArdle Laboratory for Cancer Research, University of Wisconsin, Madison.
The Tohoku Journal of Experimental Medicine
|October 1, 1992
Abstract:
The Ah locus, first described as a functional polymorphism among inbred strains of mice, encodes the Ah receptor--a ligand dependent transcriptional activator. This paper reviews the work on the Ah receptor and its importance in the expression of cytochrome P-450IA1 and the pleiotropic effects of halogenated aromatic hydrocarbons.