Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Current status in hepatitis virus research].

T Uchida1

  • 1Department of Pathology, Nihon University School of Medicine, Tokyo.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phosphorylation sites on tau by tau protein kinase I, a bovine derived kinase generating an epitope of paired helical filaments.

Neuroscience letters·1992
Same author

[Human lung cancer cell lines in our laboratory: establishment of three large cell carcinoma cell lines and their biological characterization].

Human cell·1992
Same author

[A case report of an acute promyelocytic leukemia patient showing remarkable thrombopoiesis prior to granulopoiesis by hM-CSF treatment after chemotherapy].

[Rinsho ketsueki] The Japanese journal of clinical hematology·1992
Same author

Structural requirements of peptide YY for biological activity at enteric sites.

The American journal of physiology·1992
Same author

The response to drug therapy in unstable angina on the basis of coronary angiography findings.

Japanese circulation journal·1992
Same author

[Prevalence and pathogenesis of iron deficiency in Japanese women (1981-1991)].

[Rinsho ketsueki] The Japanese journal of clinical hematology·1992
Same journal

[The Role of Laboratory Medicine in Hematopoietic Stem Cell Transplantation "Echocardiogram"].

Rinsho byori. The Japanese journal of clinical pathology·2019
Same journal

[The Significance of Pulmonary Function Testing Before and After Allogeneic Stem Cell Transplantation].

Rinsho byori. The Japanese journal of clinical pathology·2019
Same journal

[Blood Transfusion Inspection].

Rinsho byori. The Japanese journal of clinical pathology·2019
Same journal

[The Role of Clinical Laboratory Technicians at Bone Marrow Transplantation : Blood Test].

Rinsho byori. The Japanese journal of clinical pathology·2019
Same journal

[The Foundation of Allogeneic Hematopoietic Stem Cell Transplantation and the Role of Clinical Laboratory Tests in This Field].

Rinsho byori. The Japanese journal of clinical pathology·2019
Same journal

[How to Interpret Data from Routine Laboratory Tests].

Rinsho byori. The Japanese journal of clinical pathology·2019
See all related articles

Hepatitis B precore mutations can cause severe liver disease. Hepatitis C virus variations and Hepatitis E virus strains show distinct global patterns and clinical relevance.

Area of Science:

  • Virology
  • Hepatology
  • Molecular Biology

Context:

  • Chronic hepatitis B infection involves seroconversion from eAg to anti-e, linked to precore region mutations.
  • Hepatitis C virus (HCV) exhibits significant genomic variations, particularly in envelope regions containing neutralizing epitopes.
  • Hepatitis E virus (HEV) strains from Myanmar and China share high nucleotide identity, with HEV being endemic in developing nations.

Purpose:

  • To explore the molecular basis and clinical implications of viral mutations in hepatitis B, C, and E.
  • To understand the genetic diversity and geographical distribution of hepatitis viruses.
  • To highlight the significance of viral variations in disease pathogenesis and treatment.

Summary:

  • Precore G-to-A substitution (G1986A) in hepatitis B virus (HBV) leads to a stop codon, potentially causing fulminant hepatitis or chronic hepatitis B exacerbation.

Related Experiment Videos

  • Hepatitis C virus (HCV) displays high variability in its envelope genes, influencing subtype classification and potential responses to interferon therapy.
  • Hepatitis E virus (HEV) shows genetic similarity among strains from specific regions and is prevalent in developing countries, unlike industrialized nations.

    • Impact:

    • Understanding HBV precore mutations is crucial for managing severe liver disease.
    • HCV subtyping based on genetic variations may guide personalized treatment strategies.
    • The geographical distribution and genetic characteristics of HEV inform public health interventions and disease control efforts.