Related Experiment Videos
Gonadotropin secreting pituitary microadenoma
1Department of Obstetrics and Gynecology, American University, Beirut Medical Center.
Le Journal Medical Libanais. the Lebanese Medical Journal
|January 1, 1992
Summary
FSH and LH secreting pituitary adenomas are potentially common in reproductive-aged women with hypergonadotropic amenorrhea. Diagnosis is confirmed by CT scan, with treatment options including surgery or watchful waiting.
Area of Science:
- Endocrinology
- Reproductive Medicine
- Neurosurgery
Background:
- Pituitary adenomas secreting follicle-stimulating hormone (FSH) and luteinizing hormone (LH) may be underdiagnosed.
- Hypergonadotropic amenorrhea in women of reproductive age warrants investigation for pituitary causes.
Observation:
- Two cases of gonadotropin-secreting pituitary microadenomas are presented.
- Patients exhibited normal estrogenic states despite amenorrhea.
- Computerized tomography confirmed pituitary microadenomas.
Findings:
- Transsphenoidal resection was performed in both cases.
- Pituitary dynamic testing revealed normal function post-operatively.
- Ovarian biopsies showed primordial follicles and a corpus luteum, indicating varied ovarian responses.
Implications:
- The diagnosis of gonadotropin-secreting pituitary adenomas should be considered in specific clinical scenarios.
- Treatment decisions require balancing surgical risks (hypopituitarism) against expectant management.
- Further research into the natural history of these tumors is essential for guiding clinical practice.