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Updated: Aug 8, 2026
06:38
Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
Published on: November 8, 2011
[Theory of multistep lymphocyte transformation]
1Hlavův ústav 1. LF UK, Praha.
Ceskoslovenska Patologie
|August 1, 1992
Summary
B lymphocyte transformation in lymph nodes involves three sequential steps, originating from germinal centers and progressing through mantle zones to medullary areas. This process generates various effector cells and may explain hyperplastic and neoplastic conditions.
Area of Science:
- Immunology
- Cell Biology
Context:
- Lymph node structure and function
- B lymphocyte differentiation pathways
Purpose:
- To describe the multi-step transformation process of B lymphocytes within lymph nodes.
- To elucidate the cellular origins and destinations of transformed lymphocytes.
Summary:
- B lymphocyte transformation initiates from germinal center blast cells, proceeding through three distinct steps: germinal center, mantle zone, and medullary stages.
- Each step involves cellular alteration and migration, with feedback mechanisms and potential for hyperplasia.
- Specific effector cells, including lymphoplasmacytoid cells, immunocytes, autoaggressive cells, and committed blood lymphocytes/plasmacytes, are generated at different stages.
Impact:
- Provides a theoretical framework for understanding B lymphocyte transformation.
- Offers insights into the cellular composition of hyperplastic and neoplastic conditions within lymph nodes.
- Highlights the dependence of transformation on local structural and antigenic factors.
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