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Mumps meningoencephalitis; a clinical review of 119 cases with one death

H B BRUYN, H M SEXTON, H D BRAINERD

    California Medicine
    |March 1, 1957
    PubMed

    Insights

    Mumps virus is a common cause of aseptic meningitis, often without salivary gland involvement. While typically benign, this report details a rare fatal case of mumps meningoencephalitis.

    Area of Science:

    • Neurology
    • Infectious Diseases
    • Virology

    Background:

    • Mumps virus is a frequent cause of central nervous system infections.
    • It is a primary consideration in diagnosing aseptic meningitis.
    • Mumps infections do not always involve the salivary glands.

    Purpose of the Study:

    • To highlight the neurological impact of mumps virus.
    • To emphasize mumps virus in the differential diagnosis of aseptic meningitis.
    • To report a rare fatal case of mumps meningoencephalitis.

    Main Methods:

    • Literature review of mumps central nervous system infections.
    • Analysis of cerebrospinal fluid findings in mumps meningoencephalitis.
    • Case presentation of a fatal mumps meningoencephalitis.

    Main Results:

    • Mumps meningoencephalitis typically presents with mild symptoms and resolves within five days.
    • Cerebrospinal fluid characteristically shows over 200 leukocytes/mL, predominantly lymphocytes (≥80%).
    • Sequelae and mortality are exceptionally rare, making the presented fatal case noteworthy.

    Conclusions:

    • Mumps virus is a significant etiological agent of aseptic meningitis.
    • The clinical course is usually benign, but severe outcomes can occur.
    • Early consideration of mumps virus in CNS infections is crucial for diagnosis.
    Keywords:
    MENINGOENCEPHALITIS/etiology and pathogenesisMUMPS/complications

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