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[Bacterial translocation. Its role in the etiology of sepsis and multiple organ failure]
R L Zapata-Sirvent1, J F Hansbrough
1Departamento de Cirugía, University of California Medical Center, San Diego.
Abstract:
Under certain conditions or diseases the microorganisms that normally inhabited in the gastrointestinal tract reach the mesenteric lymph nodes, the portal circulation, the intra and extraperitoneal organs and the systemic circulation creating the possibility of infection, sepsis and multiple organ failure. This phenomenon has been termed bacterial translocation and although was described few decades ago, today it has regain critical importance due to the association to the multiple organ failure syndrome in critical and severely injured patients. In this review a series of pathologies where the translocation of bacteria has been demonstrated are described as well as the possible therapeutics maneuvers.
Insights
Bacterial translocation occurs when gut microbes enter circulation, potentially causing infection and organ failure, especially in critically ill patients. This review examines associated conditions and therapeutic strategies.
Area of Science:
- Microbiology
- Immunology
- Pathophysiology
Context:
- Normally, the gastrointestinal tract harbors microorganisms.
- Under specific conditions or diseases, these microbes can migrate to other body sites.
Purpose:
- To review pathologies associated with bacterial translocation.
- To discuss potential therapeutic interventions for bacterial translocation.
Summary:
- Bacterial translocation is the movement of gastrointestinal microorganisms to mesenteric lymph nodes, portal circulation, and systemic circulation.
- This phenomenon can lead to infection, sepsis, and multiple organ failure.
- It is particularly relevant in critical care and trauma patients.
Impact:
- Understanding bacterial translocation is crucial for managing critically ill patients.
- Identifying therapeutic maneuvers can help prevent or treat complications arising from bacterial translocation.