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Related Experiment Videos

Quinine blindness.

S Naraqi1, S Okem, N Moyia

  • 1Faculty of Medicine, University of Papua New Guinea, Port Moresby General Hospital.

Papua and New Guinea Medical Journal
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

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Quinine treatment for severe malaria or typhoid fever can cause sudden blindness. Prompt treatment with dexamethasone and vitamins may partially restore vision and color perception.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Pharmacology

Background:

  • Severe malaria and typhoid fever are serious infections requiring prompt treatment.
  • Intravenous quinine and chloramphenicol are commonly used antibiotics for these conditions.

Observation:

  • A young woman developed sudden, total bilateral vision loss after receiving intravenous quinine.
  • Her visual acuity was severely impaired, with constricted visual fields and absent color vision.

Findings:

  • Funduscopic examination revealed macular edema and attenuated retinal arteries.
  • Treatment with dexamethasone, cyclandelate, and vitamin supplements led to partial recovery of vision and complete color vision restoration.

Implications:

Related Experiment Videos

  • This case highlights the potential neurotoxic side effect of quinine, specifically quinine blindness.
  • Early recognition and management with corticosteroids and supportive therapies may improve visual outcomes in quinine-induced visual impairment.