[Hypercholesterolemic effect of canthaxanthin and astaxanthin in rats]

Three groups of male Wistar rats (130-140 g) were fed 30 days with a synthetic diets containing 0.1% of beta-carotene, canthaxanthin and astaxanthin respectively. Another group was fed with a synthetic diet without carotenoids. The results shows that the beta-carotene does not induce change in plasma cholesterol (49, 7 +/- 3.6 mg/dl), but canthaxanthin and astaxanthin induce a significant increase in cholesterol concentration (92.1 +/- 3.6 and 66.5 +/- 5.1 mg/dl). This increase is noted mainly in the HDL fraction of the lipoproteins. Canthaxanthin has more affinity than astaxanthin for the liver, principal site of lipoproteins catabolism. The hypercholesterolemic effect of these xanthophylls is not related to reported mechanisms of carotenoids in mammalian, because beta-carotene does not induce changes in plasma cholesterol.