Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Thrombosis and cardiovascular disease.

¹MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, Middlesex, United Kingdom.

Annals of Epidemiology

|July 1, 1992

Summary

The thrombotic component is crucial in myocardial infarction and sudden coronary death. Research shows plasma fibrinogen levels strongly predict ischemic heart disease (IHD) and stroke incidence.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Northwick Park Heart Studies: contrasts between the two factor VII assays used.

Journal of thrombosis and haemostasis : JTH·2012

Same author

Circulating markers of arterial thrombosis and late-stage age-related macular degeneration: a case-control study.

Eye (London, England)·2010

Same author

Systematically missing confounders in individual participant data meta-analysis of observational cohort studies.

Statistics in medicine·2009

Same author

Assessing the contribution of fibrinogen in predicting risk of death in men with peripheral arterial disease.

Journal of thrombosis and haemostasis : JTH·2008

Same author

The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases.

European journal of epidemiology·2007

Same author

Long-term effects of hemostatic variables on fatal coronary heart disease: 30-year results from the first prospective Northwick Park Heart Study (NPHS-I).

Journal of thrombosis and haemostasis : JTH·2006

Area of Science:

Cardiovascular Medicine
Hematology
Epidemiology

Background:

The role of thrombosis in myocardial infarction and sudden coronary death is increasingly recognized.
While platelet function is central to thrombogenesis, reliable measures linking it to ischemic heart disease (IHD) onset are lacking.
Epidemiological studies highlight the significance of hemostatic factors in IHD.

Purpose of the Study:

To review the epidemiological evidence implicating components of the hemostatic system in ischemic heart disease (IHD).
To discuss the interplay between lipoproteins, coagulability, and atherogenesis in IHD.
To emphasize the need for evaluating antithrombotic measures for primary prevention alongside lipid-lowering therapies.

Main Methods:

Review of prospective epidemiological studies assessing hemostatic factors and IHD incidence.
Analysis of laboratory studies implicating specific coagulation factors (e.g., factor VII) and the fibrinolytic system.
Consideration of the influence of lipoproteins on coagulability and atherogenesis.

Main Results:

Strong associations found between plasma fibrinogen levels and the incidence of IHD and stroke.
Factor VII and extrinsic pathway activity implicated in IHD onset.
Lipoproteins influence both coagulability and atherogenesis, suggesting a combined role in IHD.

Conclusions:

A purely atherogenic or thrombogenic hypothesis for IHD is counterproductive; both factors are involved.
Antithrombotic measures, such as low-dose aspirin, require thorough evaluation for primary IHD prevention.
Establishing the effectiveness and safety of antithrombotic versus lipid-modifying regimens is crucial for IHD management.

Related Experiment Videos