Related Experiment Video

Updated: Aug 10, 2026

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
06:43

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 8, 2013

The Atherosclerosis Risk in Communities (ARIC) Study. Introduction and objectives of the hemostasis component

A R Sharrett1

  • 1Epidemiology and Biometry Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.

Annals of Epidemiology
|July 1, 1992
PubMed

Insights

The Atherosclerosis Risk in Communities (ARIC) Study investigates atherosclerosis by measuring hemostatic factors and arterial wall thickness. This research aims to identify key etiologic factors contributing to cardiovascular disease outcomes.

Area of Science:

  • Epidemiology
  • Cardiovascular Research
  • Biomedical Science

Background:

  • The Atherosclerosis Risk in Communities (ARIC) Study is a major observational epidemiologic research initiative.
  • It focuses on understanding the causes and progression of atherosclerosis and its clinical manifestations.

Purpose of the Study:

  • To investigate etiologic factors associated with atherosclerosis.
  • To examine the relationship between hemostatic factors and early atherosclerosis.
  • To assess arterial intimal-medial wall thickness as an index of early atherosclerosis.

Main Methods:

  • Prospective cohort study design involving participants aged 45-64.
  • Measurement of hemostatic factors including fibrinogen, factor VII, factor VIII, and von Willebrand factor.
  • Ultrasound imaging to precisely measure arterial intimal-medial wall thickness in carotid and popliteal arteries.

Main Results:

  • Initial examination included 15,801 participants.
  • Measurements of coagulation factors (fibrinogen, factor VII, factor VIII, von Willebrand factor) and inhibitors (protein C, antithrombin III) were collected.
  • Future analyses will include coagulation activation, platelet activation, and fibrinolytic activity.

Conclusions:

  • The ARIC study provides a comprehensive dataset for investigating atherosclerosis etiology.
  • Hemostatic factors and arterial wall thickness are key indicators in early atherosclerosis research.
  • This research contributes to understanding cardiovascular disease risk factors.

More Related Videos

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients09:09

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients

Published on: April 3, 2026

Related Concept Videos

Introduction to Hemostasis01:05

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...