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Related Experiment Videos

Lower endogenous androgens predict central adiposity in men.

K T Khaw1, E Barrett-Connor

  • 1Department of Clinical Gerontology, University of Cambridge, School of Clinical Medicine, United Kingdom.

Annals of Epidemiology
|September 1, 1992
PubMed
Summary

Central adiposity is linked to higher cardiovascular risk. Lower levels of androstenedione and testosterone in men are associated with increased abdominal fat, challenging the "male pattern" fat distribution concept.

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Area of Science:

  • Endocrinology
  • Cardiovascular Health
  • Obesity Research

Background:

  • Central adiposity is independently associated with adverse cardiovascular outcomes.
  • The term "male pattern" fat distribution is commonly used but may be inaccurate.
  • Hormonal factors, particularly androgens, are implicated in fat distribution.

Purpose of the Study:

  • To investigate the relationship between baseline androgen levels and subsequent central adiposity in men.
  • To determine if hormonal profiles predict abdominal fat accumulation.
  • To re-evaluate the concept of "male pattern" fat distribution.

Main Methods:

  • Prospective cohort study of 511 men aged 30-79 years (1972-1974).
  • Baseline measurements included androstenedione, testosterone, and sex hormone-binding globulin.

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  • Central adiposity assessed 12 years later using waist-hip circumference ratio.

    • Main Results:

    • Higher baseline levels of androstenedione, testosterone, and sex hormone-binding globulin were inversely related to subsequent central adiposity.
    • Differences in waist-hip ratio were comparable to those observed between men with and without cardiovascular disease.
    • Total androgen levels showed a negative association with central adiposity.

    Conclusions:

    • "Male pattern" fat distribution may be a misnomer for central adiposity in men.
    • Higher androgen levels are associated with less central adiposity.
    • Further research is needed on the role of sex hormone-binding globulin in regulating androgenic activity and fat distribution.