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Updated: Aug 11, 2026

Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model
Published on: July 29, 2012
Immunoregulatory mechanisms and Chagas' disease
1Unité d'Immunoparasitologie, Institut Pasteur, Paris, France.
Abstract:
During the course of experimental Chagas' disease, several immune disorders occur. In the acute phase, T and B cell polyclonal activation is associated to immunosuppression. At the chronic stage, T cells--of the TH2 subset--participate to the pathology characteristic of Chagas' disease. Data obtained after infection of BALB/Xid mice suggest that polyclonal activation may be dependent on B1 (CD5) cell-activation. Moreover, these mice fail to develop the pathological features of the chronic infection. Control of lymphokine secretion might play a key role in the clinical status of Chagas' disease.
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