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Recent advances and prospective researches on molecular epidemiology of dengue viruses
1Laboratory of Arboviruses, Institut Pasteur, Paris, France.
Memorias Do Instituto Oswaldo Cruz
|January 1, 1992
Abstract:
The determination of amino acid changes in the envelope protein by direct sequencing of either genomic RNA or PCR-amplified cDNA fragments provides useful informations for assessing the genetic variability and the geographic distribution of the actually most widespread dengue-2 serotype. The possible link of variations in the envelope protein-gene and virus virulence is discussed.