Related Experiment Videos
[Bilateral renal agenesis: a 10-year experience]
F Viñals1, W H Sepúlveda, R Klaasen
1Servicio de Obstetricia y Ginecología, Hospital Clínico Regional Guillermo Grant Benavente, Concepción.
Revista Chilena De Obstetricia Y Ginecologia
|January 1, 1992
Summary
Bilateral renal agenesis (BRA) is a lethal birth defect affecting 0.1-0.3/1000 births. Early prenatal diagnosis is crucial for managing high-risk pregnancies complicated by BRA, improving outcomes for affected neonates.
Area of Science:
- Medical Genetics
- Developmental Biology
- Perinatology
Context:
- Bilateral renal agenesis (BRA) is a rare and uniformly lethal congenital malformation.
- It occurs in 0.1-0.3 per 1000 births and is linked to severe oligohydramnios, intrauterine growth retardation (IUGR), and extra-renal anomalies.
- BRA presents significant challenges in high-risk pregnancies, often leading to malpresentation and requiring intensive neonatal care.
Purpose:
- To present the clinical experience with 10 cases of bilateral renal agenesis over a 10-year period.
- To highlight the challenges in prenatal diagnosis and management of BRA.
- To discuss strategies for improving prenatal detection of this condition.
Summary:
- Out of 10 cases, prenatal diagnosis was achieved in only one instance.
- The majority of cases (70%) presented with malpresentation, oligohydramnios, and severe IUGR, necessitating a high rate of cesarean section (40%).
- Neonatal intensive care was provided to affected infants, underscoring the severity of the condition.
Impact:
- Emphasizes the critical need for improved prenatal diagnostic methods for bilateral renal agenesis.
- Highlights the significant impact of BRA on pregnancy management and neonatal outcomes.
- Informs clinical practice regarding the recognition and handling of high-risk pregnancies associated with BRA.