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Myocardial collagen remodeling and left ventricular diastolic function.

¹Department of Internal Medicine, University of Missouri, Columbia 65212.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas

|January 1, 1992

Summary

The heart

Area of Science:

Cardiovascular Biology
Cardiac Remodeling
Biomedical Engineering

Background:

The myocardial collagen matrix, composed mainly of collagen types I and III, is crucial for ventricular architecture, diastolic function, and mechanical properties.
This matrix interacts closely with myocytes, myofibrils, muscle fibers, and coronary vasculature, providing essential tensile strength.
Alterations in collagen are implicated in ventricular remodeling and diastolic dysfunction.

Purpose of the Study:

To investigate the role of the myocardial collagen matrix in cardiac structure and function.
To explore the impact of collagen degradation and remodeling on ventricular mechanics and diastolic function.
To understand the relationship between hormonal influences, hypertension, and collagen matrix changes in cardiac hypertrophy.

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Last Updated: Jul 18, 2026

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Main Methods:

Analysis of myocardial collagen composition and structure.
Assessment of ventricular architecture and diastolic function.
Investigation of collagen remodeling in response to hypertension and hormonal factors.

Main Results:

Collagen degradation, even less than 50%, leads to ventricular dilation and increased compliance, mirroring changes seen in ischemia and dilated cardiomyopathy.
Remodeling of the collagen matrix, including increased concentration and thickening, occurs during hypertension with elevated angiotensin and/or mineralocorticoids.
Collagen remodeling adversely affects passive mechanical properties and causes left ventricular (LV) diastolic dysfunction, independent of myocyte changes.

Conclusions:

Changes in heart size and shape are preceded by alterations in the interstitial collagen matrix.
Myocardial collagen remodeling is a key factor in the development of diastolic dysfunction during hypertrophic processes.
Targeting collagen matrix remodeling may offer therapeutic strategies for heart failure with preserved ejection fraction and other cardiac conditions.