[Pathologic mechanisms in the development of psoriatic lesions]

Psoriasis is a chronic recessive disease of unknown etiology, insufficiently explained and with a rather complex pathogenesis. In this paper the role of polymorphonuclear leukocytes, products lipids (arachidonic acid, leukotriene, 12-hydroxyeicosatetraenoic acid and the others) has been considered, as well as some immunological moments and the role of complements and platelet activating factor. It has not been explained up to now which one of these factors has the main role in the psoriatic lesion development. The primary defect in this genetically determined disease is unknown. All the elements listed in the sequence of events have secondary or tertiary significance.