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The complement system and primary biliary cirrhosis.

C Benbassat1, M Schlesinger, Y Shoenfeld

  • 1Department of Medicine B, Sheba Medical Center, Tel-Hashomer, Israel.

Journal of Clinical & Laboratory Immunology
|January 1, 1992
PubMed
Summary
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Primary biliary cirrhosis (PBC) involves autoimmune processes. This review examines the complement system

Area of Science:

  • Immunology
  • Hepatology
  • Autoimmune Diseases

Background:

  • Primary biliary cirrhosis (PBC) is a chronic liver disease with unknown causes.
  • Immunological abnormalities suggest autoimmune mechanisms in PBC pathogenesis.
  • The role of the complement system in PBC has not been thoroughly investigated.

Purpose of the Study:

  • To review existing literature on the complement system in PBC.
  • To analyze the potential involvement of complement pathways in PBC.

Main Methods:

  • Literature review of immunological and complement studies related to PBC.
  • Analysis of reported serum levels of complement components in PBC patients.

Main Results:

  • PBC exhibits various immunological abnormalities.

Related Experiment Videos

  • Serum levels of most complement components are elevated in PBC.
  • Complement component C4 is notably decreased in PBC patients.

    • Conclusions:

    • The complement system likely plays a role in the pathogenesis of PBC.
    • Further research is needed to elucidate the specific mechanisms of complement activation and its impact on PBC progression.