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Related Experiment Videos

Intracellular Ca2+ stores in neurons. Identification and functional aspects.

J Meldolesi1, A Villa, P Podini

  • 1Department of Pharmacology, CNR Cytopharmacology, Milan, Italy.

Journal of Physiology, Paris
|January 1, 1992
PubMed
Summary

Neurons contain multiple, distinct intracellular calcium (Ca2+) stores that regulate cell activity. These stores, composed of specific proteins, manage calcium levels and influence neuronal function.

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Biochemistry

Background:

  • Intracellular calcium (Ca2+) stores are crucial for neuronal signaling.
  • Understanding the diversity and function of these stores is essential for comprehending neuronal physiology.

Purpose of the Study:

  • To review the characteristics of intracellular Ca2+ stores in neurons.
  • To discuss their molecular composition and physiological significance.

Main Methods:

  • High-resolution immunocytochemistry
  • Subcellular fractionation
  • Literature review

Main Results:

  • Neurons possess multiple, distinct intracellular Ca2+ stores sensitive to inositol 1,4,5-trisphosphate or ryanodine-caffeine.

Related Experiment Videos

  • These stores regulate plasma membrane Ca2+ permeability and sustain localized intracellular Ca2+ heterogeneities.
  • Molecular components include Ca2+ ATPase, low-affinity high-capacity Ca2+ binding proteins, and Ca2+ release channels.
  • Purkinje neurons exhibit heterogeneous stores strategically distributed within cellular compartments.

    • Conclusions:

    • Intracellular Ca2+ stores are heterogeneous and strategically organized within neurons.
    • Their molecular composition supports distinct Ca2+ handling mechanisms.
    • These stores play a key role in regulating neuronal excitability and function.