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Signet cell melanocytic lesions.

V A LiVolsi¹, J J Brooks, R Soslow

¹Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc

|September 1, 1992

Summary

Signet cell melanoma presents diagnostic challenges due to its varied patterns. This study highlights signet cell patterns in both benign nevi and melanoma, aiding differential diagnosis with immunohistochemistry.

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Area of Science:

Dermatopathology
Oncology

Background:

Malignant melanoma exhibits diverse histologic patterns, posing diagnostic challenges for histopathologists.
The signet cell pattern in melanoma can be mistaken for other tumor types, including adenocarcinoma and lymphoma.

Observation:

This study reports four new cases of signet cell melanoma in primary and metastatic sites.
The signet cell pattern was observed in benign nevi, extending its recognition to melanocytic cells broadly.

Findings:

The signet cell pattern, previously recognized in melanoma, is now documented in benign nevi.
Immunohistochemical stains are crucial for differentiating signet cell melanoma from its mimics.

Implications:

Expanding the recognition of the signet cell pattern to benign nevi aids in accurate melanoma diagnosis.

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Understanding this pattern and utilizing immunohistochemistry improves diagnostic accuracy for melanocytic lesions.