Search research articles

Search research articles

Related Experiment Videos

[Omeprazole and liver functions].

P Sauvet¹, L Schouler

¹Département d'Hépato-gastro-entérologie, Hôpital du Haut-Levêque, Bordeaux-Pessac.

La Revue De Medecine Interne

|September 1, 1992

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Lemierre syndrome secondary to malignant cervical adenopathy].

Presse medicale (Paris, France : 1983)·2000

Same author

[Severity of Hirschsprung's disease in the adult].

Gastroenterologie clinique et biologique·1998

Same author

[Appearance of hepatitis C virus replication and increase of aminotransferase activity after corticoid treatment of presumed autoimmune hepatitis. 2 cases].

Gastroenterologie clinique et biologique·1996

Same author

[Acute kidney failure after a tam-tam concert].

Presse medicale (Paris, France : 1983)·1995

Same author

[Remission of autoimmune thrombopenic purpura after low-dose splenic irradiation].

Presse medicale (Paris, France : 1983)·1993

Same author

[Follicular gastritis in adults. Relations with Helicobacter pylori, histological and endoscopic aspects].

Gastroenterologie clinique et biologique·1993

Same journal

[Abdominal pain, fever and arthralgia in a 49-year-old woman].

La Revue de medecine interne·2026

Same journal

[Cardiorespiratory functional disorders: A transnosologic approach].

La Revue de medecine interne·2026

Same journal

[Diagnostic evaluation for suspected polycythemia].

La Revue de medecine interne·2026

Same journal

Heart involvements in systemic sclerosis beyond pulmonary hypertension: From conduction, rhythm and function defects to coronary artery disease.

La Revue de medecine interne·2026

Same journal

[Acute intermittent porphyria: When diagnostic errance jeopardizes patient health].

La Revue de medecine interne·2026

Same journal

Autosomal dominant polycystic kidney disease: Current perspectives in 2026.

La Revue de medecine interne·2026

See all related articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Omeprazole, a proton pump blocker, effectively reduces stomach acid for short-term use. While generally safe, it interacts with liver enzymes, necessitating caution with other medications metabolized similarly.

Area of Science:

Pharmacology
Hepatology

Background:

Omeprazole is a novel proton pump blocker approved for acid-related disorders.
It exhibits high efficacy in inhibiting gastric acid secretion.

Purpose of the Study:

To evaluate the safety profile of omeprazole, particularly regarding hepatotoxicity and drug interactions.
To assess omeprazole's use in patients with chronic liver disease.

Main Methods:

Review of reported clinical data on omeprazole's effects.
Analysis of omeprazole's interaction with the cytochrome P-450 system in vitro and in vivo.
Assessment of pharmacokinetic changes in patients with liver disease.

Main Results:

Omeprazole can cause transient elevations in serum aminotransferase levels.

Related Experiment Videos

It inhibits and induces cytochrome P-450 enzymes, affecting the metabolism of other drugs like diazepam and phenytoin.

Concerns regarding increased tumorigenic effects are considered unfounded based on current evidence.

Conclusions:

Omeprazole is generally well-tolerated with a low incidence of side effects.
Caution is advised when co-prescribing omeprazole with drugs metabolized by the same liver enzymes.
Postmarketing surveillance is recommended to monitor for potential drug interactions.