Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Overdose with sustained-release lithium preparations.

G M Bosse1, T C Arnold

  • 1Department of Emergency Medicine, University of Louisville, Kentucky.

The Journal of Emergency Medicine
|November 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cell column chromatography: a new research tool to quantify cerebral cell volume changes following chemically-induced anoxia/re-oxygenation.

Acta neurochirurgica. Supplement·2006
Same author

Ifenprodil treatment is associated with a down-regulation of brain aquaporin 4 following cardiac arrest in rats.

Acta neurochirurgica. Supplement·2006
Same author

Peripheral neuropathy in workers exposed to nitromethane.

American journal of industrial medicine·2001
Same author

Detection of cocaine metabolite in serum and urine: frequency and correlation with medical diagnosis.

Clinica chimica acta; international journal of clinical chemistry·2000
Same author

Delayed toxidromes.

The Journal of emergency medicine·1999
Same author

Aspiration of activated charcoal elicits an increase in lung microvascular permeability.

Journal of toxicology. Clinical toxicology·1999

Sustained-release lithium overdose can cause delayed toxicity, even with initial normal levels. Monitor patients closely as lithium levels may rise to toxic ranges hours after ingestion.

Area of Science:

  • Pharmacology
  • Clinical Toxicology

Background:

  • Lithium is a mood stabilizer commonly prescribed for bipolar disorder.
  • Sustained-release formulations aim to provide stable therapeutic lithium levels.
  • Overdose management requires understanding drug pharmacokinetics.

Observation:

  • Two cases of overdose involving sustained-release lithium preparations were documented.
  • Initial serum lithium concentrations were within therapeutic or subtherapeutic ranges.
  • Delayed increases in serum lithium levels to toxic ranges were observed.

Findings:

  • Sustained-release lithium can exhibit delayed toxicity following overdose.
  • Initial monitoring may not accurately reflect the peak toxic potential.
  • The pharmacokinetic profile of sustained-release lithium contributes to this phenomenon.

Related Experiment Videos

Implications:

  • Clinicians must be aware of the risk of delayed lithium toxicity.
  • Extended monitoring of serum lithium levels is crucial after overdose.
  • This highlights the importance of careful dosing and patient education for sustained-release lithium.