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Measurement of non-steroid antiinflammatory drugs induced gastric microbleeding
Abstract:
The damage of the mucous membranes in the gastrointestinal tract caused by non-steroid antiinflammatory drugs are well known. The gastrointestinal microbleeding was measured by the method of Fischer and Hunt before and after the intake of indomethacin (4 x 25 mg), naproxen-sodium (4 x 275 mg), diclofenac (3 x 50 mg) and azapropazone (2 x 600 mg). In the indomethacin group microbleeding increased from 0.91 +/- 0.12 ml/24 h to 7.30 +/- 1.20 ml/h. In the naproxen-sodium group from 1.22 +/- 0.16 ml/24 h to 3.56 +/- 0.40 ml/24 h, in the diclofenac group from 0.86 +/- 0.14 ml/24 h to 3.18 +/- 0.28 ml/24 h, in azapropazone group from 0.92 +/- 0.18 ml/24 h to 2.50 +/- 0.20 ml/24 h, respectively. All non-steroid antiinflammatory drugs increased the gastric microbleeding, however, there were considerable differences in the degree of enhancement. This can be explained by the different inhibitory activities of the drugs on the cyclooxygenase enzyme activity.
Insights
Non-steroid anti-inflammatory drugs (NSAIDs) increase gastrointestinal microbleeding. Indomethacin showed the most significant increase, while all tested NSAIDs elevated bleeding, likely due to varying cyclooxygenase inhibition.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Non-steroid anti-inflammatory drugs (NSAIDs) are widely used for pain and inflammation.
- NSAID use is associated with gastrointestinal mucosal damage.
Purpose of the Study:
- To quantify gastrointestinal microbleeding induced by common NSAIDs.
- To compare the effects of indomethacin, naproxen-sodium, diclofenac, and azapropazone on gastric microbleeding.
Main Methods:
- Gastrointestinal microbleeding was measured using the Fischer and Hunt method.
- Measurements were taken before and after administration of specific NSAID dosages.
- Drugs tested: indomethacin, naproxen-sodium, diclofenac, and azapropazone.
Main Results:
- All tested NSAIDs significantly increased gastric microbleeding.
- Indomethacin caused the largest increase in microbleeding (0.91 to 7.30 ml/24h).
- Naproxen-sodium, diclofenac, and azapropazone also increased microbleeding, with varying degrees.
Conclusions:
- NSAIDs exacerbate gastric microbleeding.
- The extent of microbleeding increase varies among different NSAIDs.
- Differences in cyclooxygenase enzyme inhibition likely explain the varying effects of NSAIDs.