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Diet and blood nutrient correlations with ischemic heart, hypertensive heart, and stroke mortality in China
Insights
Cardiovascular disease is a leading cause of death. This study identified dietary and lifestyle factors, including molybdenum and age at first pregnancy, linked to heart disease and stroke in China.
Area of Science:
- Epidemiology
- Cardiovascular Disease Research
- Nutritional Science
Background:
- Cardiovascular disease (CVD) is a primary cause of mortality globally, affecting both Asian Chinese and Western populations.
- Understanding the interplay of biochemical, dietary, and lifestyle factors is crucial for CVD prevention strategies.
Purpose of the Study:
- To investigate the associations between various biochemical, dietary, and lifestyle factors and cardiovascular mortality in China.
- To identify specific risk and protective factors for ischemic heart disease, hypertensive heart disease, and stroke.
Main Methods:
- Analysis of data from two large-scale surveys conducted in China.
- Statistical examination of correlations between cardiovascular mortality and selected biochemical markers, dietary components, and lifestyle habits.
Main Results:
- Negative correlations with ischemic heart disease: molybdenum, oleic acid, liquor consumption (males), legumes, and age at first pregnancy.
- Negative correlations with hypertensive heart disease: molybdenum, oleic acid (females), and age at first pregnancy.
- Negative correlations with stroke: legumes and age at first pregnancy.
- Positive correlations with ischemic heart disease: triglycerides and herpes antibodies.
- Positive correlations with hypertensive heart disease: salt and phosphorus (females).
- Positive correlation with stroke: albumin (males).
- Findings partially align with Western studies (salt, triglycerides, herpes, legumes, oleic acid, liquor), highlighting novel factors like molybdenum and age at first pregnancy.
Conclusions:
- Molybdenum and age at first pregnancy emerge as significant factors associated with cardiovascular disease risk in the studied Chinese population.
- Dietary (legumes, oleic acid, salt, phosphorus) and lifestyle (liquor consumption) factors show varied associations with different cardiovascular outcomes.
- The study underscores the importance of considering unique regional factors in cardiovascular disease research, complementing established Western observations.
Abstract:
Though major differences exist in subcategory mortality levels, cardiovascular disease remains a leading cause of death among both Asian Chinese and Westerners. This paper examines the possible relationship between cardiovascular mortality and biochemical, diet and lifestyle factors based on two surveys in China. Statistically significant associations indicate five variables negatively correlated: molybdenum, oleic acid, liquor consumption (males), legumes, and age at first pregnancy with ischemic heart disease; molybdenum, oleic acid (females) and age at first pregnancy with hypertensive heart disease; and legumes and age at first pregnancy with stroke. Five variables were positively correlated: triglycerides and herpes antibodies with ischemic heart disease; salt and phosphorus (females) with hypertensive heart disease; and only albumin (males) with stroke. Some findings confirm those observed in the West (salt, triglycerides, herpes, legumes, oleic acid, and liquor), but molybdenum and age at first pregnancy have not been emphasized previously. Still others significant in the West have not been observed here, such as cholesterol and smoking.