Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Magnetic resonance imaging in multiple sclerosis: an overview.

M Colosimo1, A Amatruda, R P Cioffi

  • 1Servizio di Radiologia e Medicina Nucleare, Ospedale Cristo Re, Roma.

Italian Journal of Neurological Sciences
|December 1, 1992
PubMed
Summary

Magnetic Resonance Imaging (MRI) is crucial for diagnosing multiple sclerosis (MS), detecting lesions in space and time. MRI also reveals disease activity and aids in evaluating treatment effectiveness for MS patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Direct antimicrobial susceptibility testing (AST) from positive blood cultures using Microscan system for early detection of bacterial resistance phenotypes.

Diagnostic microbiology and infectious disease·2021
Same author

Polyomavirus BK replication in liver transplant candidates with normal renal function.

Transplantation proceedings·2011
Same author

Retrospective evaluation of adverse drug reactions induced by nonsteroidal anti-inflammatory drugs.

Clinical drug investigation·2007
Same author

Retrospective analysis of adverse drug reactions induced by gemcitabine treatment in patients with non-small cell lung cancer.

Pharmacological research·2004
Same author

Retrospective analysis of adverse drug reactions to bronchodilators observed in two pulmonary divisions of Catanzaro, Italy.

Pharmacological research·2003
Same author

Adverse drug reactions to antibiotics observed in two pulmonology divisions of catanzaro, Italy: a six-year retrospective study.

Pharmacological research·2002

Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Multiple Sclerosis (MS) diagnosis relies heavily on imaging.
  • Magnetic Resonance Imaging (MRI) has rapidly become the preferred diagnostic tool for suspected MS.
  • MRI excels at assessing lesion dissemination in space and time.

Purpose of the Study:

  • To highlight the diagnostic and research utility of MRI in multiple sclerosis.
  • To underscore MRI's role in understanding MS pathogenesis.
  • To emphasize MRI's potential in evaluating therapeutic interventions for MS.

Main Methods:

  • Utilizing serial Magnetic Resonance Imaging (MRI) scans.
  • Employing Gadolinium-DTPA (Gd-DTPA) enhanced MRI to track lesion evolution.
  • Analyzing MRI findings to assess lesion dissemination and disease activity.

Related Experiment Videos

Main Results:

  • MRI is the optimal paraclinical test for evaluating lesion dissemination in space and time in MS.
  • Serial Gd-DTPA-enhanced MRI facilitates monitoring of lesion evolution.
  • MRI detects asymptomatic lesions, indicating ongoing disease activity independent of clinical symptoms.
  • Focal breakdown of the blood-brain barrier (BBB) is identified as an early event in MS lesion development via MRI.

Conclusions:

  • MRI is indispensable for diagnosing multiple sclerosis (MS) and assessing disease progression.
  • MRI provides critical insights into the pathogenesis of MS, particularly regarding blood-brain barrier integrity.
  • MRI serves as a vital tool for evaluating the efficacy of new treatments in clinical trials for MS.